Red blood cells (RBC) have great potential as drug delivery systems, capable of producing unprecedented changes in pharmacokinetics, pharmacodynamics, and immunogenicity.
Despite this great potential and nearly 50 years of research, it is only recently that RBC-mediated drug delivery has begun to move out of the academiclab and into industrial drug development. RBC loading with drugs can be performed in several ways-either via encapsulation within the RBC or surface coupling, and either ex vivo or in vivo-depending on the intended application.
In this review, we briefly summarize currently used technologies for RBC loading/coupling with an eye on how pharmacokinetics is impacted. Additionally, we provide a detailed description of key ADME (absorption, distribution, metabolism, elimination) changes that would be expected for RBC-associated drugs and address unique features of RBC pharmacokinetics.
BIO-acetoxime |
B5488-25 |
ApexBio |
25 mg |
EUR 374 |
BIO-acetoxime |
B5488-5 |
ApexBio |
5 mg |
EUR 137 |
BIO-acetoxime |
B5488-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 189 |
BIO 1211 |
A8663-1 |
ApexBio |
1 mg |
EUR 324 |
Description: BIO 1211 is a selective and high affinity inhibitor of ?4?1 with IC50 value of 0.004uM [1].The leukocyte integrin ?4?1 mediates leukocyte recruitment, activation, apoptosis inhibition and mediator release, it plays an important role in inflammatory responses [1]. |
BIO 5192 |
B7741-10 |
ApexBio |
10 mg |
EUR 470 |
Description: BIO5192 is a small molecule inhibitor of integrin ?4?1 with an IC50 value of 1.8 ± 0.7 nM [1].Integrin ?4?1 is important in inflammatory processes. |
BIO 5192 |
B7741-50 |
ApexBio |
50 mg |
EUR 1819 |
Description: BIO5192 is a small molecule inhibitor of integrin ?4?1 with an IC50 value of 1.8 ± 0.7 nM [1].Integrin ?4?1 is important in inflammatory processes. |
meter bio-electronic |
C3050 |
Consort |
ea |
EUR 1197 |
Bio-SAM b |
ACT00202-100 |
Arthus |
100µg |
EUR 543 |
Description: Biotin is conjugated to NH2 group of S-adenosylmethionine. |
Bio-SAM a |
ACT00202-50 |
Arthus |
50µg |
EUR 319 |
Description: Biotin is conjugated to NH2 group of S-adenosylmethionine. |
Bio-SAH b |
ACT00302-100 |
Arthus |
100µg |
EUR 543 |
Description: Biotin is conjugated to NH2 group of S-adenosylhomocysteine. |
Bio-SAH a |
ACT00302-50 |
Arthus |
50µg |
EUR 319 |
Description: Biotin is conjugated to NH2 group of S-adenosylhomocysteine. |
Sealing film, qPCR Optical (sticky adhesive film) Bio-Rad Type, 100/pk |
P1001-Q |
MTC Bio |
100/pack |
EUR 122.9 |
Description: Sealing film qPCR Optical (sticky adhesive film) Bio-Rad Type |
Bio-6C-SAM 1b |
ACT00203-100 |
Arthus |
100µg |
EUR 728 |
Description: Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid. |
Bio-6C-SAM 1a |
ACT00203-50 |
Arthus |
50µg |
EUR 416 |
Description: Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid. |
Bio-6C-SAH 1b |
ACT00303-100 |
Arthus |
100µg |
EUR 806 |
Description: Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid. |
Bio-6C-SAH 1a |
ACT00303-50 |
Arthus |
50µg |
EUR 475 |
Description: Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid. |
Bio-12CN-SAH 1a |
ACT00305-10 |
Arthus |
10µg |
EUR 202 |
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. |
Bio-12CN-SAH 1c |
ACT00305-100 |
Arthus |
100µg |
EUR 923 |
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. |
Bio-12CN-SAH 1b |
ACT00305-50 |
Arthus |
50µg |
EUR 533 |
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. |
BIO, 6-Bromoindirubin-3′-Oxime |
BC2001-001 |
GenDepot |
1mg |
EUR 182 |
BIO, 6-Bromoindirubin-3′-Oxime |
BC2001-010 |
GenDepot |
10 mg |
EUR 313 |
BIO, 6-Bromoindirubin-3′-Oxime |
BC2001-050 |
GenDepot |
50 mg |
EUR 840 |
kit c3050 bio-electronic agro |
C3050A |
Consort |
ea |
EUR 1839 |
GSK-3 Inhibitor IX (BIO) |
B1538-10 |
ApexBio |
10 mg |
EUR 168 |
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?). |
GSK-3 Inhibitor IX (BIO) |
B1538-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 174 |
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?). |
GSK-3 Inhibitor IX (BIO) |
B1538-50 |
ApexBio |
50 mg |
EUR 512 |
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?). |
Bio-6C-aza-SAM 1a |
ACT00205-10 |
Arthus |
10µg |
EUR 202 |
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. |
Bio-6C-aza-SAM 1c |
ACT00205-100 |
Arthus |
100µg |
EUR 933 |
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. |
Bio-6C-aza-SAM 1b |
ACT00205-50 |
Arthus |
50µg |
EUR 543 |
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. |
Bio-12CN-aza-SAM 1a |
ACT00206-10 |
Arthus |
10µg |
EUR 241 |
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. |
Bio-12CN-aza-SAM 1c |
ACT00206-100 |
Arthus |
100µg |
EUR 1030 |
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. |
Bio-12CN-aza-SAM 1b |
ACT00206-50 |
Arthus |
50µg |
EUR 631 |
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. |
ExoPure? Isolation Kit (Bio Fluids) |
K1241-10 |
Biovision |
|
EUR 697 |
ExoPure? Isolation Kit (Bio Fluids) |
K1241-2 |
Biovision |
|
EUR 403 |
Tyr[0] Neurokinin A Antibody |
11061-05011 |
AssayPro |
150 ug |
EUR 217 |
Tyr[0] Neurokinin A Antibody (Biotin Conjugate) |
11061-05021 |
AssayPro |
150 ug |
EUR 276 |
Synapsin Blocking Peptide |
33R-11061 |
Fitzgerald |
50 ug |
EUR 191 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Synapsin antibody, catalog no. 70R-12465 |
Bio-Star Mastermix (2X) Low-ROX |
P150 |
GeneOn |
100 rcs (2,5 ml) |
EUR 102 |
MultiBox for Western blotting, 2 compartments, 85 x 85 x 30mm each (311/32 x 311/32 x 13/16 in.), for Novex Mini (8x8cm), Bio-Rad Mini (7x8cm) and others |
B1212 |
MTC Bio |
6/pack |
EUR 100.63 |
Description: Western Blot Boxes |
DISH,BIO ASSAY,SQUARE,LOW PROFILE,S,BK,5/20 |
431301 |
CORNING |
5/pk |
EUR 197 |
Description: Lab Cell Culture; BioAssay Dishes |
SensiFAST Lyo-Ready No-ROX Mix, 2x |
BIO-11060 |
Cusabio |
10 x 10ml |
Ask for price |
BIOTAQ DNA Polymerase |
BIO-21040 |
Bioline |
500 Units |
Ask for price |
IMMOLASE DNA Polymerase |
BIO-21046 |
Bioline |
250 Units |
Ask for price |
IMMOLASE DNA Polymerase |
BIO-21047 |
Bioline |
500 Units |
Ask for price |
IMMOLASE DNA Polymerase |
BIO-21048 |
Bioline |
5000 Units |
Ask for price |
ACCUZYME DNA Polymerase |
BIO-21051 |
Bioline |
250 Units |
Ask for price |
ACCUZYME DNA Polymerase |
BIO-21052 |
Bioline |
500 Units |
Ask for price |
BIOTAQ DNA Polymerase |
BIO-21060 |
Bioline |
2500 Units |
Ask for price |
MangoTaq DNA Polymerase |
BIO-21078 |
Bioline |
5000 Units |
Ask for price |
MangoTaq DNA Polymerase |
BIO-21082 |
Bioline |
2000 Units |
Ask for price |
MangoTaq DNA Polymerase |
BIO-21083 |
Bioline |
1000 Units |
Ask for price |
VELOCITY DNA Polymerase |
BIO-21098 |
Bioline |
250 Units |
Ask for price |
VELOCITY DNA Polymerase |
BIO-21099 |
Bioline |
500 Units |
Ask for price |
MyTaq DNA Polymerase |
BIO-21105 |
Bioline |
500 units |
Ask for price |
MyTaq DNA Polymerase |
BIO-21106 |
Bioline |
2500 units |
Ask for price |
MyTaq DNA Polymerase |
BIO-21107 |
Bioline |
5000 units |
Ask for price |
MyTaq Red DNA Polymerase |
BIO-21108 |
Bioline |
500 units |
Ask for price |
MyTaq Red DNA Polymerase |
BIO-21109 |
Bioline |
2500 units |
Ask for price |
MyTaq Red DNA Polymerase |
BIO-21110 |
Bioline |
5000 units |
Ask for price |
MyTaq HS DNA Polymerase |
BIO-21111 |
Bioline |
250 units |
Ask for price |
MyTaq HS DNA Polymerase |
BIO-21112 |
Bioline |
1000 units |
Ask for price |
MyTaq HS DNA Polymerase |
BIO-21113 |
Bioline |
2500 units |
Ask for price |
MyTaq HS Red DNA Polymerase |
BIO-21115 |
Bioline |
1000 units |
Ask for price |
MyTaq HS Red DNA Polymerase |
BIO-21116 |
Bioline |
2500 units |
Ask for price |
MyFi DNA Polymerase |
BIO-21117 |
Bioline |
250 Units |
Ask for price |
MyFi DNA Polymerase |
BIO-21118 |
Bioline |
500 Units |
Ask for price |
MyFi DNA Polymerase |
BIO-21119 |
Bioline |
2500 Units |
Ask for price |
Ranger DNA Polymerase |
BIO-21121 |
Bioline |
250 Units |
Ask for price |
Ranger DNA Polymerase |
BIO-21122 |
Bioline |
500 Units |
Ask for price |
MyTaq Extract-PCR Kit |
BIO-21126 |
Bioline |
100 Reactions |
Ask for price |
MyTaq Extract-PCR Kit |
BIO-21127 |
Bioline |
500 Reactions |
Ask for price |
BioMix Red, 2x |
BIO-25006 |
Bioline |
500 Reactions |
Ask for price |
BioMix, 2x |
BIO-25012 |
Bioline |
500 Reactions |
Ask for price |
ImmoMix, 2x |
BIO-25020 |
Bioline |
500 Reactions |
Ask for price |
ImmoMix Red, 2x |
BIO-25022 |
Bioline |
500 Reactions |
Ask for price |
ACCUZYME Mix, 2x |
BIO-25028 |
Bioline |
500 Reactions |
Ask for price |
MangoMix, 2x |
BIO-25033 |
Bioline |
250 Reactions |
Ask for price |
MangoMix, 2x |
BIO-25034 |
Bioline |
1000 Reactions |
Ask for price |
MyTaq Mix, 2x |
BIO-25041 |
Bioline |
200 Reactions |
Ask for price |
MyTaq Mix, 2x |
BIO-25042 |
Bioline |
1000 Reactions |
Ask for price |
MyTaq Red Mix, 2x |
BIO-25043 |
Bioline |
200 Reactions |
Ask for price |
MyTaq Red Mix, 2x |
BIO-25044 |
Bioline |
1000 Reactions |
Ask for price |
MyTaq HS Mix, 2x |
BIO-25045 |
Bioline |
200 Reactions |
Ask for price |
MyTaq HS Mix, 2x |
BIO-25046 |
Bioline |
1000 Reactions |
Ask for price |
MyTaq HS Red Mix, 2x |
BIO-25047 |
Bioline |
200 Reactions |
Ask for price |
MyTaq HS Red Mix, 2x |
BIO-25048 |
Bioline |
1000 Reactions |
Ask for price |
MyFi Mix, 2x |
BIO-25049 |
Bioline |
100 Reactions |
Ask for price |
MyFi Mix, 2x |
BIO-25050 |
Bioline |
500 Reactions |
Ask for price |
Ranger Mix, 2x |
BIO-25052 |
Bioline |
500 Reactions |
Ask for price |
As thorough understanding of pharmacokinetics is critical in successful translation to the clinic, we expect that this review will provide a jumping off point for further investigations into this area.