Vascular Drug Delivery Using Carrier Red Blood Cells: Focus on RBC Surface Loading and Pharmacokinetics.

Red blood cells (RBC) have great potential as drug delivery systems, capable of producing unprecedented changes in pharmacokinetics, pharmacodynamics, and immunogenicity.

Despite this great potential and nearly 50 years of research, it is only recently that RBC-mediated drug delivery has begun to move out of the academiclab and into industrial drug development. RBC loading with drugs can be performed in several ways-either via encapsulation within the RBC or surface coupling, and either ex vivo or in vivo-depending on the intended application.

In this review, we briefly summarize currently used technologies for RBC loading/coupling with an eye on how pharmacokinetics is impacted. Additionally, we provide a detailed description of key ADME (absorption, distribution, metabolism, elimination) changes that would be expected for RBC-associated drugs and address unique features of RBC pharmacokinetics.

BIO-X-ACT Short Mix, 2x

BIO-25026 500 Reactions Ask for price

BIO

1673-1
EUR 158

BIO

GL6265-1MG 1 mg
EUR 126

BIO

GL6265-25MG 25 mg
EUR 447

BIO

GL6265-5MG 5 mg
EUR 195

BIO-acetoxime

B5488-25 25 mg
EUR 374

BIO-acetoxime

B5488-5 5 mg
EUR 137

BIO-acetoxime

B5488-5.1 10 mM (in 1mL DMSO)
EUR 189

BIO 5192

B7741-10 10 mg
EUR 470
Description: BIO5192 is a small molecule inhibitor of integrin ?4?1 with an IC50 value of 1.8 ± 0.7 nM [1].Integrin ?4?1 is important in inflammatory processes.

BIO 5192

B7741-50 50 mg
EUR 1819
Description: BIO5192 is a small molecule inhibitor of integrin ?4?1 with an IC50 value of 1.8 ± 0.7 nM [1].Integrin ?4?1 is important in inflammatory processes.

BIO 1211

A8663-1 1 mg
EUR 324
Description: BIO 1211 is a selective and high affinity inhibitor of ?4?1 with IC50 value of 0.004uM [1].The leukocyte integrin ?4?1 mediates leukocyte recruitment, activation, apoptosis inhibition and mediator release, it plays an important role in inflammatory responses [1].

BIO-acetoxime

HY-15356 100mg
EUR 899

Azido-Cy5 tyramide

11061 1 mg
EUR 306
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12171501

Bio-SAM b

ACT00202-100 100µg
EUR 543
Description: Biotin is conjugated to NH2 group of S-adenosylmethionine.

Bio-SAM a

ACT00202-50 50µg
EUR 319
Description: Biotin is conjugated to NH2 group of S-adenosylmethionine.

Bio-SAH b

ACT00302-100 100µg
EUR 543
Description: Biotin is conjugated to NH2 group of S-adenosylhomocysteine.

Bio-SAH a

ACT00302-50 50µg
EUR 319
Description: Biotin is conjugated to NH2 group of S-adenosylhomocysteine.

meter bio-electronic

C3050 ea
EUR 1197

Sealing film, qPCR Optical (sticky adhesive film) Bio-Rad Type, 100/pk

P1001-Q 100/pack
EUR 122.9
Description: Sealing film qPCR Optical (sticky adhesive film) Bio-Rad Type

Bio-6C-SAM 1b

ACT00203-100 100µg
EUR 728
Description: Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid.

Bio-6C-SAM 1a

ACT00203-50 50µg
EUR 416
Description: Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid.

Bio-6C-SAH 1b

ACT00303-100 100µg
EUR 806
Description: Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid.

Bio-6C-SAH 1a

ACT00303-50 50µg
EUR 475
Description: Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid.

Bio-12CN-SAH 1a

ACT00305-10 10µg
EUR 202
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker.

Bio-12CN-SAH 1c

ACT00305-100 100µg
EUR 923
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker.

Bio-12CN-SAH 1b

ACT00305-50 50µg
EUR 533
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker.

BIO-11006 acetate salt

HY-106377A 10mM/1mL
EUR 821

pTT3- CD109- bio- His

PVT10241 2 ug
EUR 301

GSK-3 Inhibitor IX (BIO)

B1538-10 10 mg
EUR 168
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?).

GSK-3 Inhibitor IX (BIO)

B1538-5.1 10 mM (in 1mL DMSO)
EUR 174
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?).

GSK-3 Inhibitor IX (BIO)

B1538-50 50 mg
EUR 512
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?).

Bio-6C-aza-SAM 1a

ACT00205-10 10µg
EUR 202
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid.

Bio-6C-aza-SAM 1c

ACT00205-100 100µg
EUR 933
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid.

Bio-6C-aza-SAM 1b

ACT00205-50 50µg
EUR 543
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid.

Bio-12CN-aza-SAM 1a

ACT00206-10 10µg
EUR 241
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker.

Bio-12CN-aza-SAM 1c

ACT00206-100 100µg
EUR 1030
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker.

Bio-12CN-aza-SAM 1b

ACT00206-50 50µg
EUR 631
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker.

kit c3050 bio-electronic agro

C3050A ea
EUR 1839

BIO, 6-Bromoindirubin-3′-Oxime

BC2001-001 1mg
EUR 182

BIO, 6-Bromoindirubin-3′-Oxime

BC2001-010 10 mg
EUR 313

BIO, 6-Bromoindirubin-3′-Oxime

BC2001-050 50 mg
EUR 840

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10
EUR 697

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2
EUR 403

Synapsin Blocking Peptide

33R-11061 50 ug
EUR 191
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Synapsin antibody, catalog no. 70R-12465

Tyr[0] Neurokinin A Antibody

11061-05011 150 ug
EUR 217

Tyr[0] Neurokinin A Antibody (Biotin Conjugate)

11061-05021 150 ug
EUR 276

Bio-Star Mastermix for probes (2X)

P120 100 rcs (2,5 ml)
EUR 94

Bio-Star Mastermix (2X) High-ROX

P140 100 rcs (2,5 ml)
EUR 102

Bio-Star Mastermix (2X) Low-ROX

P150 100 rcs (2,5 ml)
EUR 102

Bio-Star Mastermix with SYBR (2X) BLUE

Y220 100 rcs (2,5 ml)
EUR 94

MultiBox for Western blotting, 2 compartments, 85 x 85 x 30mm each (311/32 x 311/32 x 13/16 in.), for Novex Mini (8x8cm), Bio-Rad Mini (7x8cm) and others

B1212 6/pack
EUR 100.63
Description: Western Blot Boxes

Bio-Star Mastermix with SYBR (2X) no dye

Y210 100 rcs (2,5 ml)
EUR 89

Bio-Star Mastermix with SYBR (2X) High-ROX

Y240 100 rcs (2,5 ml)
EUR 102

Bio-Star Mastermix with SYBR (2X) Low-ROX

Y250 100 rcs (2,5 ml)
EUR 102

DISH,BIO ASSAY,SQUARE,LOW PROFILE,S,BK,5/20

431301 5/pk
EUR 197
Description: Lab Cell Culture; BioAssay Dishes

Biotin Labeling Kit

55R-BIO 1 mg
EUR 813
Description: Biotin labeling kit for IgG

SensiFAST Lyo-Ready No-ROX Mix, 2x

BIO-11060 10 x 10ml Ask for price

BIOTAQ DNA Polymerase

BIO-21040 500 Units Ask for price

IMMOLASE DNA Polymerase

BIO-21046 250 Units Ask for price

IMMOLASE DNA Polymerase

BIO-21047 500 Units Ask for price

IMMOLASE DNA Polymerase

BIO-21048 5000 Units Ask for price

ACCUZYME DNA Polymerase

BIO-21051 250 Units Ask for price

ACCUZYME DNA Polymerase

BIO-21052 500 Units Ask for price

BIOTAQ DNA Polymerase

BIO-21060 2500 Units Ask for price

MangoTaq DNA Polymerase

BIO-21078 5000 Units Ask for price

MangoTaq DNA Polymerase

BIO-21082 2000 Units Ask for price

MangoTaq DNA Polymerase

BIO-21083 1000 Units Ask for price

VELOCITY DNA Polymerase

BIO-21098 250 Units Ask for price

VELOCITY DNA Polymerase

BIO-21099 500 Units Ask for price

MyTaq DNA Polymerase

BIO-21105 500 units Ask for price

MyTaq DNA Polymerase

BIO-21106 2500 units Ask for price

MyTaq DNA Polymerase

BIO-21107 5000 units Ask for price

MyTaq Red DNA Polymerase

BIO-21108 500 units Ask for price

MyTaq Red DNA Polymerase

BIO-21109 2500 units Ask for price

MyTaq Red DNA Polymerase

BIO-21110 5000 units Ask for price

MyTaq HS DNA Polymerase

BIO-21111 250 units Ask for price

MyTaq HS DNA Polymerase

BIO-21112 1000 units Ask for price

MyTaq HS DNA Polymerase

BIO-21113 2500 units Ask for price

MyTaq HS Red DNA Polymerase

BIO-21115 1000 units Ask for price

MyTaq HS Red DNA Polymerase

BIO-21116 2500 units Ask for price

MyFi DNA Polymerase

BIO-21117 250 Units Ask for price

MyFi DNA Polymerase

BIO-21118 500 Units Ask for price

MyFi DNA Polymerase

BIO-21119 2500 Units Ask for price

Ranger DNA Polymerase

BIO-21121 250 Units Ask for price

Ranger DNA Polymerase

BIO-21122 500 Units Ask for price

MyTaq Extract-PCR Kit

BIO-21126 100 Reactions Ask for price

MyTaq Extract-PCR Kit

BIO-21127 500 Reactions Ask for price

BioMix Red, 2x

BIO-25006 500 Reactions Ask for price

BioMix, 2x

BIO-25012 500 Reactions Ask for price

ImmoMix, 2x

BIO-25020 500 Reactions Ask for price

ImmoMix Red, 2x

BIO-25022 500 Reactions Ask for price

ACCUZYME Mix, 2x

BIO-25028 500 Reactions Ask for price

MangoMix, 2x

BIO-25033 250 Reactions Ask for price

MangoMix, 2x

BIO-25034 1000 Reactions Ask for price

MyTaq Mix, 2x

BIO-25041 200 Reactions Ask for price

MyTaq Mix, 2x

BIO-25042 1000 Reactions Ask for price

MyTaq Red Mix, 2x

BIO-25043 200 Reactions Ask for price

MyTaq Red Mix, 2x

BIO-25044 1000 Reactions Ask for price

As thorough understanding of pharmacokinetics is critical in successful translation to the clinic, we expect that this review will provide a jumping off point for further investigations into this area.