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Yang Xie Lab | Quantitative Biomedical Research Center | Department of Population and Data Sciences | UT Southwestern | UTSW

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Drug discovery for primary amebic meningoencephalitis: from screen to identification of leads

Drug discovery for primary amebic meningoencephalitis: from screen to identification of leads

April 7, 2021 by Rosa Jenkins

Naegleria fowleri is accountable for primary amebic meningoencephalitis (PAM) which has a fatality fee of >97%. Because of the rarity of the illness, pharmaceutical firms don’t pursue new drug discovery for PAM. Yet, it’s potential that the an infection is underreported and discovering a greater drug would have an effect on individuals struggling from this lethal an infection.This paper studies the efforts undertaken by completely different educational teams over the past 20 years to check completely different compounds towards N. fowleri.

The drug discovery analysis encompassed synthesis of new compounds, growth and use of high-throughput screening strategies and makes an attempt to repurpose clinically developed or FDA-approved compounds for the therapy of PAM. In absence of financial funding to develop new medicine for PAM, repurposing the FDA-approved medicine has been the most effective technique up to now to determine new leads towards N. fowleri. Increasing use of high-throughput phenotypic screening has the potential to speed up the identification of new leads, both in monotherapy or together therapy. Since section II medical trial shouldn’t be potential for PAM, it’s vital to display in vivo efficacy of a clinically protected compound to translate the discovery from lab to the clinic.

Visit-to-visit blood strain (BP) variability (BPV) is an unbiased threat issue of heart problems (CVD). Sleep structure characterizes the distribution of completely different phases of sleep and could also be necessary in CVD growth. We examined the affiliation between visit-to-visit BPV and sleep structure utilizing in-lab polysomnographic information from 3,565 sufferers referred to an educational sleep middle. BPV was calculated utilizing the intra-individual coefficient of variation of BP measures collected 12 months earlier than the sleep research. We performed a number of linear regression analyses to assess the affiliation of systolic and diastolic BPV with sleep architecture-rapid eye motion (REM) and non-rapid eye motion (NREM) sleep period.

Our outcomes present that systolic BPV was inversely related to REM sleep period (p = .058). When sufferers have been divided into tertile teams primarily based on their BPV, these within the third tertile (highest variability) spent 2.7 fewer minutes in REM sleep than these within the first tertile (lowest variability, p = .032), after adjusting for covariates. We didn’t discover an affiliation of systolic BPV with different measures of sleep structure. Diastolic BPV was not related to sleep structure both. In abstract, our research confirmed that better systolic BPV was related to decrease REM sleep period. Future investigation is warranted to make clear the directionality, mechanism, and therapeutic implications.

Histological options in pediatric central nervous system tumors with FGFR alterations

Identification of genetic alterations in central nervous system (CNS) tumors offers diagnostic and prognostic data and permits identification of potential therapeutic targets. Next-generation sequencing (NGS) applied sciences presently used for molecular testing are expensive and stay largely restricted to main educational facilities or reference labs. Identification of histologic or immunohistochemical correlates for specific molecular alterations can function surrogates and will help triage circumstances for subsequent NGS-based affirmation. Recently, grownup IDH-wildtype grownup glioblastomas (GBMs) with fibroblast progress issue receptor (FGFR) gene alterations have been reported to present palisading monomorphic cells, delicate arcuate vasculature, and microcalcifications. We explored whether or not pediatric tumors with FGFR fusion additionally present these histologic options and whether or not these options might predict the presence of this gene alteration.
We reviewed pediatric CNS tumors with FGFR-fusions to retrospectively decide the presence/absence of the above-mentioned histological options in fusion-positive tumors.  10 pediatric tumors with FGFR fusions have been recognized. Pediatric tumors demonstrated histologic and tumor sort range, with diagnoses of pilocytic/pilomyxoid astrocytoma, pediatric-type oligodendroglioma, anaplastic astrocytoma, polymorphous low-grade neuroepithelial tumor of the younger, rosette-forming glioneuronal tumor, and extraventricular neurocytoma.  Pediatric FGFR-fused CNS tumors display histologic options related to their grownup counterparts but in addition exhibit vital morphologic variability. As such, this histologic variability prevents the prediction of FGFR fusion and necessitates molecular testing for the identification of this alteration.
 Drug discovery for primary amebic meningoencephalitis: from screen to identification of leads

The National COVID Cohort Collaborative: Clinical Characterization and Early Severity Prediction

The majority of U.S. studies of COVID-19 medical traits, illness course, and coverings are from single well being methods or centered on one area. Here we report the creation of the National COVID Cohort Collaborative (N3C), a centralized, harmonized, high-granularity digital well being file repository that’s the largest, most consultant U.S. cohort of COVID-19 circumstances and controls to date. This multi-center dataset helps sturdy evidence-based growth of predictive and diagnostic instruments and informs vital care and coverage. In a retrospective cohort research of 1,926,526 sufferers from 34 medical facilities nationwide, we stratified sufferers utilizing a World Health Organization COVID-19 severity scale and demographics; we then evaluated variations between teams over time utilizing multivariable logistic regression.
We established important indicators and laboratory values amongst COVID-19 sufferers with completely different severities, offering the inspiration for predictive analytics. The cohort included 174,568 adults with extreme acute respiratory syndrome related to SARS-CoV-2 (PCR >99% or antigen <1%) in addition to 1,133,848 grownup sufferers that served as lab-negative controls. Among 32,472 hospitalized sufferers, mortality was 11.6% general and decreased from 16.4% in March/April 2020 to 8.6% in September/October 2020 (p = 0.002 month-to-month development). In a multivariable logistic regression mannequin, age, male intercourse, liver illness, dementia, African-American and Asian race, and weight problems have been independently related to larger medical severity.

Goat Glutathione peroxidase ELISA kit

E06G0369-96 BlueGene 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Glutathione peroxidase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Eosinophil peroxidase(EPX) ELISA kit

E06E0383-192T BlueGene 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Eosinophil peroxidase(EPX) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Eosinophil peroxidase(EPX) ELISA kit

E06E0383-48 BlueGene 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Eosinophil peroxidase(EPX) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Eosinophil peroxidase(EPX) ELISA kit

E06E0383-96 BlueGene 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Eosinophil peroxidase(EPX) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutathione Peroxidase 1 ELISA kit

E06G0234-192T BlueGene 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Glutathione Peroxidase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutathione Peroxidase 1 ELISA kit

E06G0234-48 BlueGene 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Glutathione Peroxidase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutathione Peroxidase 1 ELISA kit

E06G0234-96 BlueGene 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Glutathione Peroxidase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutathione Peroxidase (GPX) ELISA Kit

abx257781-96tests Abbexa 96 tests
EUR 864

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-48T DL Develop 48T
EUR 554
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-96T DL Develop 96T
EUR 725
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-48Tests Reddot Biotech 48 Tests
EUR 563

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-96Tests Reddot Biotech 96 Tests
EUR 783

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-48Tests Reddot Biotech 48 Tests
EUR 589

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-96Tests Reddot Biotech 96 Tests
EUR 820

Goat Anti Thyroid peroxidase antibody ELISA kit

E06T0531-192T BlueGene 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Anti Thyroid peroxidase antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Anti Thyroid peroxidase antibody ELISA kit

E06T0531-48 BlueGene 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Anti Thyroid peroxidase antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Anti Thyroid peroxidase antibody ELISA kit

E06T0531-96 BlueGene 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Anti Thyroid peroxidase antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

GPX1 ELISA Kit| Goat Glutathion peroxidase ELISA Kit

EF012589 Lifescience Market 96 Tests
EUR 689

Horseradish Peroxidase Goat Anti-Chicken IgY

CH23104 Neuromics 400 ul
EUR 344

Goat Anti-Biotin-HRP (Peroxidase) conjugate

20361 Alpha Diagnostics 0.5 ml
EUR 164

Goat Epididymal secretory glutathione peroxidase(GPX5) ELISA kit

E06E0389-192T BlueGene 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Epididymal secretory glutathione peroxidase(GPX5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Epididymal secretory glutathione peroxidase(GPX5) ELISA kit

E06E0389-48 BlueGene 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Epididymal secretory glutathione peroxidase(GPX5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Epididymal secretory glutathione peroxidase(GPX5) ELISA kit

E06E0389-96 BlueGene 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Epididymal secretory glutathione peroxidase(GPX5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

GenomeCoV19 Detection Kit

G628.v2 ABM 100 Rxns
EUR 320
Description: The most affordable qPCR Detection Kit for SARS-CoV-2 on the market.abm’s GenomeCoV19 Detection Kit is a real-time reverse transcription-polymerase chain reaction (RT-qPCR) test intended for the qualitative detection of RNA from SARS-CoV-2 in human nasopharyngeal and oropharyngeal swab specimens from individuals suspected of COVID-19 by their healthcare provider. Our GenomeCoV19 Detection Kit is the most affordable qPCR detection kit on the market at only $1.77 USD/test (limited time pricing for US customers only).This kit is widely used in Europe under the CE-IVD certification and is listed by U.S. Food and Drug Administration (FDA) for distribution in the USA, under Section IV.C.

Senescence Detection Kit

55R-1370 Fitzgerald 250 tests
EUR 712
Description: Senescence Detection Kit for use in the research laboratory

Formaldehyde Detection Kit

K001-F1 Arbor Assays 2x96 well plate
EUR 425

Senescence Detection Kit

K320-250 Biovision
EUR 468

Autophagy Detection Kit

abx299014-50tests Abbexa 50 tests
EUR 523

Autophagy Detection Kit

abx299015-200tests Abbexa 200 tests
EUR 871

HMGB1 Detection Kit

6010 Chondrex 1 kit
EUR 753.25
Description: HMGB1 Detection Kit

Ubiquitin Detection Kit

SKT-131-20 Stressmarq 20 assays
EUR 495
Description: Purification Detection kit used to capture, detect, identify and characterise ubiquitinated proteins and free chains from samples. in Cell Lysates, Tissue samples from all species

Glutathione Detection Kit

SKT-202-96 Stressmarq 1 plate of 96 wells
EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Apoptosis Detection Kit

ANXVKB-100T ImmunoStep 100 test
EUR 464.7

Apoptosis Detection Kit

ANXVKCFB-100T ImmunoStep 100 test
EUR 412.7

Apoptosis Detection Kit

ANXVKCFB7-100T ImmunoStep 100 test
EUR 412.7

Apoptosis Detection Kit

ANXVKDY-100T ImmunoStep 100 test
EUR 389.3

Apoptosis Detection Kit

ANXVKF-100T ImmunoStep 100 test
EUR 329.5

Apoptosis Detection Kit

ANXVKF7-100T ImmunoStep 100 test
EUR 329.5

Apoptosis Detection Kit

ANXVKPE-100T ImmunoStep 100 test
EUR 346.4

Senescence Detection Kit

K2030-250 ApexBio 250 Staining
EUR 460

Goat Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(GPX4) ELISA kit

E06P0808-192T BlueGene 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(GPX4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(GPX4) ELISA kit

E06P0808-48 BlueGene 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(GPX4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(GPX4) ELISA kit

E06P0808-96 BlueGene 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Phospholipid hydroperoxide glutathione peroxidase, mitochondrial(GPX4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Frit Kit

FRIT-KIT Next Advance 1each
EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Peroxidase Assay Kit

Z5030052 Biochain 100 assays
EUR 622
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Peroxidase Assay Kit

abx298828-100Assays Abbexa 100 Assays
EUR 425

Goat anti-Rabbit IgG SecondaryAntibody (peroxidase conjugated)

E0L3012-1 EnoGene 500ul
EUR 128

Goat anti-Rabbit IgG SecondaryAntibody (peroxidase conjugated)

E0L3012-2 EnoGene 1000ul
EUR 180

Goat anti-Mouse IgG SecondaryAntibody (peroxidase conjugated)

E0L3032-1 EnoGene 500ul
EUR 128

Peroxidase

GL1218-100MG Glentham Life Sciences 100 mg
EUR 110

Peroxidase

GL1218-1G Glentham Life Sciences 1 g
EUR 517

Peroxidase

GL1218-250MG Glentham Life Sciences 250 mg
EUR 190

Peroxidase

GL1218-25MG Glentham Life Sciences 25 mg
EUR 62

Peroxidase

GL1218-500MG Glentham Life Sciences 500 mg
EUR 309

Column Packing Kit

PACK-KIT Next Advance 1pack
EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

ExoAb Antibody Kit (CD9, CD63, CD81, Hsp70 antibodies, rabbit anti-human) with goat anti-rabbit HRP secondary antibody

EXOAB-KIT-1 SBI 25 ul each
EUR 627

Super Sensitive FITC IF Detection System Kit (Goat Anti-Mouse)

abx097198-1Kit Abbexa 1 Kit
EUR 272

Super Sensitive FITC IF Detection System Kit (Goat Anti-Rabbit)

abx097199-1Kit Abbexa 1 Kit
EUR 272

Super Sensitive FITC IF Detection System Kit (Mouse Anti-Goat)

abx097200-1Kit Abbexa 1 Kit
EUR 272

Super Sensitive TRITC IF Detection System Kit (Goat Anti-Mouse)

abx097202-1Kit Abbexa 1 Kit
EUR 272

Super Sensitive TRITC IF Detection System Kit (Goat Anti-Rabbit)

abx097203-1Kit Abbexa 1 Kit
EUR 272

Super Sensitive TRITC IF Detection System Kit (Mouse Anti-Goat)

abx097204-1Kit Abbexa 1 Kit
EUR 272

Goat Anti Human Glutathione Peroxidase 1 Polyclonal Antibody

CPBT-67462GH Creative Diagnostics 0.1 mg
EUR 840

Polyclonal Goat Anti-Glutathione Peroxidase 1 (isoform1) Antibody

AMM04993G Leading Biology 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Glutathione Peroxidase 1 (isoform1) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-Glutathione peroxidase 2 (Int) Antibody

AMM04994G Leading Biology 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Glutathione peroxidase 2 (Int) . This antibody is tested and proven to work in the following applications:

Goat Anti-horse radish peroxidase (HRP) conjugate IgG

HRP11-A Alpha Diagnostics 1 mg
EUR 408

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT SBI 1 kit (10 rxn)
EUR 1110

Mycoplasma PCR Detection Kit

K1476-100 Biovision 100 Rxns
EUR 298

MitoCapture Apoptosis Detection Kit

55R-1305 Fitzgerald 25 assays
EUR 277
Description: Apoptosis Kit for detection of apoptosis in the research laboratory

Thiol Fluorescent Detection Kit

K005-F1 Arbor Assays 1x96 well plate
EUR 318

Glutathione Fluorescent Detection Kit

K006-F1 Arbor Assays 1x96 well plate
EUR 354

DNA Methylation Detection Kit

K5082100 Biochain 1 kit
EUR 344

Senescence Detection Kit (Fluorometric)

K991-100 Biovision
EUR 718

PCR-Salmonella Detection Kit

K1447-96 Biovision
EUR 620

PCR-STEC Detection Kit

K1452-96 Biovision
EUR 784

PCR-Campylobacter Detection Kit

K1453-96 Biovision
EUR 784

Residual SDS Detection Kit

BSP055 Bio Basic 100Assays
EUR 83.06

Luciferase Mycoplasma Detection Kit

20-abx298016 Abbexa
  • EUR 1010.00
  • EUR 300.00
  • EUR 425.00
  • 200 rxns
  • 25 rxns
  • 50 rxns

PCR Mycoplasma Detection Kit

abx298017-100rxns Abbexa 100 rxns
EUR 314

Protein A Detection Kit

abx090813-1Kit Abbexa 1 Kit
EUR 1581

Luciferase Mycoplasma Detection Kit

20-abx098882 Abbexa
  • EUR 1233.00
  • EUR 523.00
  • EUR 648.00
  • 200rxns
  • 25 rxns
  • 50 rxns

PCR Mycoplasma Detection Kit

abx098883-100rxns Abbexa 100 rxns
EUR 537

Mouse Albumin Detection Kit

3012 Chondrex 1 kit
EUR 483.55
Description: Mouse Albumin Detection Kit

Rat Albumin Detection Kit

3020 Chondrex 1 kit
EUR 483.55
Description: Rat Albumin Detection Kit

Ubiquitin Interact Detection Kit

SKT-132-20 Stressmarq 20 assays
EUR 464
Description: Purification Detection kit used to capture, detect, identify and characterise isolated ubiquitin binding proteins by Western blotting or proteomic analysis in samples. in Cell Lysates, Tissue samples from all species

Urine Creatinine Detection Kit

SKT-200-192 Stressmarq 2 plates of 96 wells
EUR 342
Description: Direct Detection kit used for quantitative measuring creatinine in Urine samples from Human, Monkey, Dog, Rat

Nitric Oxide Detection Kit

SKT-212-96 Stressmarq 2 plates of 96 wells
EUR 342
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Hydrogen Peroxide Detection Kit

SKT-216-192 Stressmarq 2 plates of 96 wells
EUR 441
Description: Direct Colorimetric assay used for quantitative measuring H2O2 in a variety of samples in Urine, Buffer, Tissue Culture Media samples from all species

Creatinine Serum Detection Kit

SKT-217-192 Stressmarq 2 plates of 96 wells
EUR 342
Description: Direct Colorimetric assay used to measure creatinine in Serum, Plasma samples from Human, Mouse, Rabbit, Rat, Sheep

MitoStep + Apoptosis Detection Kit

KMAF-100T ImmunoStep 100 test
EUR 420.5

Mycoplasma Detection Kit (OKSB00010)

OKSB00010 Aviva Systems Biology 50 Tests
EUR 382
Description: Description of target: ;Species reactivity: ;Application: PCR;Assay info: ;Sensitivity:

CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV100PA-KIT SBI 1 Kit
EUR 1132

CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV105PA-KIT SBI 1 Kit
EUR 1132

MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV120PA-KIT SBI 1 Kit
EUR 1132

MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV125PA-KIT SBI 1 Kit
EUR 1132

Plant Peroxidase ELISA Kit

ELA-E1419Pl Lifescience Market 96 Tests
EUR 928

Glutathione Peroxidase Assay Kit

55R-1522 Fitzgerald 100 assays
EUR 706
Description: Assay Kit for detection of Glutathione Reductase in the research laboratory

Thyroid peroxidase ELISA kit

55R-ORG503 Fitzgerald 96 wells
EUR 372
Description: ELISA kit for the detection of Thyroid peroxidase in the research laboratory

QuantiChrom Peroxidase Assay Kit

D2PD-100 BioAssay Systems 100
EUR 351
Description: Quantitative determination of peroxidase activity by colorimetric (570nm) or fluorometric (530nm/590nm) methods. Procedure: 20 min. Kit size: 100 tests. Detection limit: 0.8 U/L. Shelf life: 3 months. Shipping: ambient temp; storage: 4, -20°C.

Glutathione Peroxidase Assay Kit

20-abx294002 Abbexa
  • EUR 300.00
  • EUR 347.00
  • 24 tests
  • 48 tests

Ascorbate Peroxidase Assay Kit

abx298818-100Assays Abbexa 100 Assays
EUR 566

Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS700A-KIT SBI 10 rxn
EUR 1132

Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS720A-KIT SBI 10 rxn
EUR 1132

Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS740A-KIT SBI 10 rxn
EUR 1132

T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)

CAS510A-KIT SBI 1 Kit
EUR 805

Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV200PA-KIT SBI 1 Kit
EUR 1132

Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV205PA-KIT SBI 1 Kit
EUR 1132

Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV220PA-KIT SBI 1 Kit
EUR 1132

Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV225PA-KIT SBI 1 Kit
EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS750A-KIT SBI 10 rxn
EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS770A-KIT SBI 10 rxn
EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS790A-KIT SBI 10 rxn
EUR 1132

Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)]

CAS9LIG-KIT SBI 1 Kit
EUR 153

ExtrAvidin Peroxidase

abx082602-1ml Abbexa 1 ml
EUR 1038

Horseradish Peroxidase

7-02983 CHI Scientific 20mg Ask for price

Horseradish Peroxidase

7-02984 CHI Scientific 60mg Ask for price

Horseradish Peroxidase

7-02985 CHI Scientific 1g Ask for price

Horseradish Peroxidase

RP-1467 Alpha Diagnostics 20 mg
EUR 408

PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN320A-KIT SBI 1 Kit
EUR 4941

PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN340iPS-KIT SBI 1 Kit
EUR 4941

Peroxidase, horseradish (Horseradish peroxidase - HRP), Rz >3.0

PB0691 Bio Basic 100mg
EUR 141.35

CRISPR Genomic Cleavage Detection Kit

G932 ABM 25 Reactions
EUR 205

TUNEL FITC Apoptosis Detection Kit

A111-01 Vazyme 20 rxn
EUR 283

TUNEL FITC Apoptosis Detection Kit

A111-02 Vazyme 50 rxn
EUR 409

TUNEL FITC Apoptosis Detection Kit

A111-03 Vazyme 100 rxn
EUR 539

TUNEL BrightGreen Apoptosis Detection Kit

A112-01 Vazyme 20 rxn
EUR 306

TUNEL BrightGreen Apoptosis Detection Kit

A112-02 Vazyme 50 rxn
EUR 456

TUNEL BrightGreen Apoptosis Detection Kit

A112-03 Vazyme 100 rxn
EUR 655

TUNEL BrightRed Apoptosis Detection Kit

A113-01 Vazyme 20 rxn
EUR 306

TUNEL BrightRed Apoptosis Detection Kit

A113-02 Vazyme 50 rxn
EUR 456

TUNEL BrightRed Apoptosis Detection Kit

A113-03 Vazyme 100 rxn
EUR 655

Cholesterol Detection Kit (cell-based)

K587-100 Biovision
EUR 294

Copper Detection Assay Kit (Fluorometric)

K899-100 Biovision
EUR 457

CRISPR Genomic Cleavage Detection Kit

K1250-25 Biovision
EUR 403

PCR-Salmonella-Listeria Detection Kit

K1448-96 Biovision
EUR 784

PCR-Listeria monocytogenes Detection Kit

K1449-96 Biovision
EUR 648
To display the utility of the N3C cohort for analytics, we used machine studying (ML) to predict medical severity and threat elements over time. Using 64 inputs available on the primary hospital day, we predicted a extreme medical course (demise, discharge to hospice, invasive air flow, or extracorporeal membrane oxygenation) utilizing random forest and XGBoost fashions (AUROC 0.86 and 0.87 respectively) that have been steady over time. The strongest predictors in these fashions are affected person age and broadly available important signal and laboratory values. The established anticipated trajectories for many important indicators and laboratory values amongst sufferers with completely different medical severities validates observations from smaller research, and offers complete perception into COVID-19 characterization in U.S. sufferers.
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In vitro three-dimensional organotypic culture models of the oral mucosa
Trauma Technical Skill and Management Exposure for Junior Surgical Residents – The “SAVE Lab 1.0”.

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  • Simple isolation and characterization of seminal plasma extracellular vesicle and its total RNA in an academic lab.
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  • NAD (Nicotinamide adenine dinucleotide)
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  • Pilot Production of SARS-CoV-2 Related Proteins in Plants: A Proof of Concept for Rapid Repurposing of Indoor Farms Into Biomanufacturing Facilities
  • Trauma Technical Skill and Management Exposure for Junior Surgical Residents – The “SAVE Lab 1.0”.

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