Vascular Drug Delivery Using Carrier Red Blood Cells: Focus on RBC Surface Loading and Pharmacokinetics.

Red blood cells (RBC) have great potential as drug delivery systems, capable of producing unprecedented changes in pharmacokinetics, pharmacodynamics, and immunogenicity.

Despite this great potential and nearly 50 years of research, it is only recently that RBC-mediated drug delivery has begun to move out of the academiclab and into industrial drug development. RBC loading with drugs can be performed in several ways-either via encapsulation within the RBC or surface coupling, and either ex vivo or in vivo-depending on the intended application.

In this review, we briefly summarize currently used technologies for RBC loading/coupling with an eye on how pharmacokinetics is impacted. Additionally, we provide a detailed description of key ADME (absorption, distribution, metabolism, elimination) changes that would be expected for RBC-associated drugs and address unique features of RBC pharmacokinetics.

BIO-X-ACT Short Mix, 2x

BIO-25026 500 Reactions Ask for price

BIO

1673-1
EUR 158.00

BIO

GL6265-1MG 1 mg
EUR 126.00

BIO

GL6265-25MG 25 mg
EUR 447.00

BIO

GL6265-5MG 5 mg
EUR 195.00

BIO 1211

A8663-1 1 mg
EUR 324.00
Description: BIO 1211 is a selective and high affinity inhibitor of ?4?1 with IC50 value of 0.004uM [1].The leukocyte integrin ?4?1 mediates leukocyte recruitment, activation, apoptosis inhibition and mediator release, it plays an important role in inflammatory responses [1].

BIO 5192

B7741-10 10 mg
EUR 470.00
Description: BIO5192 is a small molecule inhibitor of integrin ?4?1 with an IC50 value of 1.8 ± 0.7 nM [1].Integrin ?4?1 is important in inflammatory processes.

BIO 5192

B7741-50 50 mg
EUR 1819.00
Description: BIO5192 is a small molecule inhibitor of integrin ?4?1 with an IC50 value of 1.8 ± 0.7 nM [1].Integrin ?4?1 is important in inflammatory processes.

BIO-acetoxime

B5488-25 25 mg
EUR 374.00

BIO-acetoxime

B5488-5 5 mg
EUR 137.00

BIO-acetoxime

B5488-5.1 10 mM (in 1mL DMSO)
EUR 189.00

BIO-acetoxime

HY-15356 100mg
EUR 899.00

Azido-Cy5 tyramide

11061 1 mg
EUR 306.00
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12171501

Bio-SAM b

ACT00202-100 100µg
EUR 543.00
Description: Biotin is conjugated to NH2 group of S-adenosylmethionine.

Bio-SAM a

ACT00202-50 50µg
EUR 319.00
Description: Biotin is conjugated to NH2 group of S-adenosylmethionine.

Bio-SAH b

ACT00302-100 100µg
EUR 543.00
Description: Biotin is conjugated to NH2 group of S-adenosylhomocysteine.

Bio-SAH a

ACT00302-50 50µg
EUR 319.00
Description: Biotin is conjugated to NH2 group of S-adenosylhomocysteine.

meter bio-electronic

C3050 ea
EUR 1197.00

pTT3- CD109- bio- His

PVT10241 2 ug
EUR 301.00

Bio-6C-SAM 1b

ACT00203-100 100µg
EUR 728.00
Description: Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid.

Bio-6C-SAM 1a

ACT00203-50 50µg
EUR 416.00
Description: Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid.

Bio-6C-SAH 1b

ACT00303-100 100µg
EUR 806.00
Description: Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid.

Bio-6C-SAH 1a

ACT00303-50 50µg
EUR 475.00
Description: Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid.

Bio-12CN-SAH 1a

ACT00305-10 10µg
EUR 202.00
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker.

Bio-12CN-SAH 1c

ACT00305-100 100µg
EUR 923.00
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker.

Bio-12CN-SAH 1b

ACT00305-50 50µg
EUR 533.00
Description: Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker.

BIO-11006 acetate salt

HY-106377A 10mM/1mL
EUR 821.00

GSK-3 Inhibitor IX (BIO)

B1538-10 10 mg
EUR 168.00
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?).

GSK-3 Inhibitor IX (BIO)

B1538-5.1 10 mM (in 1mL DMSO)
EUR 174.00
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?).

GSK-3 Inhibitor IX (BIO)

B1538-50 50 mg
EUR 512.00
Description: GSK-3 inhibitor IX (BIO) is a potent, selective, cell-permeable, ATP-competitive and reversible inhibitor of GSK-3? (glycogen synthase kinase-3?) and GSK-3? (lycogen synthase kinase-3?) (IC50 = 5nM for GSK-3?).

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10
EUR 697.00

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2
EUR 403.00

Bio-6C-aza-SAM 1a

ACT00205-10 10µg
EUR 202.00
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid.

Bio-6C-aza-SAM 1c

ACT00205-100 100µg
EUR 933.00
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid.

Bio-6C-aza-SAM 1b

ACT00205-50 50µg
EUR 543.00
Description: Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid.

Bio-12CN-aza-SAM 1a

ACT00206-10 10µg
EUR 241.00
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker.

Bio-12CN-aza-SAM 1c

ACT00206-100 100µg
EUR 1030.00
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker.

Bio-12CN-aza-SAM 1b

ACT00206-50 50µg
EUR 631.00
Description: Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker.

kit c3050 bio-electronic agro

C3050A ea
EUR 1839.00

BIO, 6-Bromoindirubin-3′-Oxime

BC2001-001 1mg
EUR 182.00

BIO, 6-Bromoindirubin-3′-Oxime

BC2001-010 10 mg
EUR 313.00

BIO, 6-Bromoindirubin-3′-Oxime

BC2001-050 50 mg
EUR 840.00

Synapsin Blocking Peptide

33R-11061 50 ug
EUR 191.00
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Synapsin antibody, catalog no. 70R-12465

Tyr[0] Neurokinin A Antibody

11061-05011 150 ug
EUR 217.00

Tyr[0] Neurokinin A Antibody (Biotin Conjugate)

11061-05021 150 ug
EUR 276.00

Bio-Star Mastermix for probes (2X)

P120 100 rcs (2,5 ml)
EUR 94.00

Bio-Star Mastermix (2X) High-ROX

P140 100 rcs (2,5 ml)
EUR 102.00

Bio-Star Mastermix (2X) Low-ROX

P150 100 rcs (2,5 ml)
EUR 102.00

COVID-19 IgG & IgM antibody Coronavirus

GEN-50001 -50tests 50 tests
EUR 324.00
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

COVID-19 IgG & IgM antibody

GEN-50001-50tests 50 tests
EUR 324.00
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

Bio-Star Mastermix with SYBR (2X) BLUE

Y220 100 rcs (2,5 ml)
EUR 94.00

Bio-Star Mastermix with SYBR (2X) no dye

Y210 100 rcs (2,5 ml)
EUR 89.00

Bio-Star Mastermix with SYBR (2X) High-ROX

Y240 100 rcs (2,5 ml)
EUR 102.00

Bio-Star Mastermix with SYBR (2X) Low-ROX

Y250 100 rcs (2,5 ml)
EUR 102.00

DISH,BIO ASSAY,SQUARE,LOW PROFILE,S,BK,5/20

431301 5/pk
EUR 197.00
Description: Lab Cell Culture; BioAssay Dishes

SensiFAST Lyo-Ready No-ROX Mix, 2x

BIO-11060 10 x 10ml Ask for price

BIOTAQ DNA Polymerase

BIO-21040 500 Units Ask for price

IMMOLASE DNA Polymerase

BIO-21046 250 Units Ask for price

IMMOLASE DNA Polymerase

BIO-21047 500 Units Ask for price

IMMOLASE DNA Polymerase

BIO-21048 5000 Units Ask for price

ACCUZYME DNA Polymerase

BIO-21051 250 Units Ask for price

ACCUZYME DNA Polymerase

BIO-21052 500 Units Ask for price

BIOTAQ DNA Polymerase

BIO-21060 2500 Units Ask for price

MangoTaq DNA Polymerase

BIO-21078 5000 Units Ask for price

MangoTaq DNA Polymerase

BIO-21082 2000 Units Ask for price

MangoTaq DNA Polymerase

BIO-21083 1000 Units Ask for price

VELOCITY DNA Polymerase

BIO-21098 250 Units Ask for price

VELOCITY DNA Polymerase

BIO-21099 500 Units Ask for price

MyTaq DNA Polymerase

BIO-21105 500 units Ask for price

MyTaq DNA Polymerase

BIO-21106 2500 units Ask for price

MyTaq DNA Polymerase

BIO-21107 5000 units Ask for price

MyTaq Red DNA Polymerase

BIO-21108 500 units Ask for price

MyTaq Red DNA Polymerase

BIO-21109 2500 units Ask for price

MyTaq Red DNA Polymerase

BIO-21110 5000 units Ask for price

MyTaq HS DNA Polymerase

BIO-21111 250 units Ask for price

MyTaq HS DNA Polymerase

BIO-21112 1000 units Ask for price

MyTaq HS DNA Polymerase

BIO-21113 2500 units Ask for price

MyTaq HS Red DNA Polymerase

BIO-21115 1000 units Ask for price

MyTaq HS Red DNA Polymerase

BIO-21116 2500 units Ask for price

MyFi DNA Polymerase

BIO-21117 250 Units Ask for price

MyFi DNA Polymerase

BIO-21118 500 Units Ask for price

MyFi DNA Polymerase

BIO-21119 2500 Units Ask for price

Ranger DNA Polymerase

BIO-21121 250 Units Ask for price

Ranger DNA Polymerase

BIO-21122 500 Units Ask for price

MyTaq Extract-PCR Kit

BIO-21126 100 Reactions Ask for price

MyTaq Extract-PCR Kit

BIO-21127 500 Reactions Ask for price

BioMix Red, 2x

BIO-25006 500 Reactions Ask for price

BioMix, 2x

BIO-25012 500 Reactions Ask for price

ImmoMix, 2x

BIO-25020 500 Reactions Ask for price

ImmoMix Red, 2x

BIO-25022 500 Reactions Ask for price

ACCUZYME Mix, 2x

BIO-25028 500 Reactions Ask for price

MangoMix, 2x

BIO-25033 250 Reactions Ask for price

MangoMix, 2x

BIO-25034 1000 Reactions Ask for price

MyTaq Mix, 2x

BIO-25041 200 Reactions Ask for price

MyTaq Mix, 2x

BIO-25042 1000 Reactions Ask for price

MyTaq Red Mix, 2x

BIO-25043 200 Reactions Ask for price

MyTaq Red Mix, 2x

BIO-25044 1000 Reactions Ask for price

MyTaq HS Mix, 2x

BIO-25045 200 Reactions Ask for price

MyTaq HS Mix, 2x

BIO-25046 1000 Reactions Ask for price

MyTaq HS Red Mix, 2x

BIO-25047 200 Reactions Ask for price

MyTaq HS Red Mix, 2x

BIO-25048 1000 Reactions Ask for price

MyFi Mix, 2x

BIO-25049 100 Reactions Ask for price

MyFi Mix, 2x

BIO-25050 500 Reactions Ask for price

Ranger Mix, 2x

BIO-25052 500 Reactions Ask for price

MyTaq Blood PCR Mix, 2x

BIO-25054 250 Reactions Ask for price

MyTaq Plant-PCR Kit

BIO-25055 250 reactions Ask for price

MyTaq Plant-PCR Kit

BIO-25056 500 reactions Ask for price

Quick-Stick Ligase

BIO-27027 50 Reactions Ask for price

Quick-Stick Ligase

BIO-27028 100 Reactions Ask for price

BioScript

BIO-27036 10,000 Units Ask for price

Uracil DNA-Glycosilase (UDGase)

BIO-27044 500 Units Ask for price

SensiFAST HRM Kit

BIO-32005 500 rxns Ask for price

SensiFAST HRM Kit

BIO-32020 2000 rxns Ask for price

HyperLadder 1kb

BIO-33025 200 Lanes Ask for price

HyperLadder 1kb

BIO-33026 500 Lanes Ask for price

HyperLadder 100bp

BIO-33029 200 Lanes Ask for price

HyperLadder 100bp

BIO-33030 500 Lanes Ask for price

HyperLadder 25bp

BIO-33031 200 Lanes Ask for price

HyperLadder 25bp

BIO-33032 500 Lanes Ask for price

HyperLadder 50bp

BIO-33039 200 Lanes Ask for price

HyperLadder 50bp

BIO-33040 500 Lanes Ask for price

EasyLadder I

BIO-33045 200 Lanes Ask for price

EasyLadder I

BIO-33046 500 Lanes Ask for price

HyperLadder 1kb

BIO-33053 100 Lanes Ask for price

HyperLadder 50bp

BIO-33054 100 Lanes Ask for price

HyperLadder 100bp

BIO-33056 100 Lanes Ask for price

HyperLadder 25bp

BIO-33057 100 Lanes Ask for price

HyperPAGE Prestained Protein Marker

BIO-33066 500µl Ask for price

SensiFAST Genotyping Lo-Rox Kit

BIO-34005 500 Reactions Ask for price

SensiFAST Genotyping Lo-ROX Mix

BIO-34020 2000 rxns Ask for price

SensiFAST Genotyping Hi-Rox Kit

BIO-35005 500 Reactions Ask for price

SensiFAST Genotyping Hi-ROX Mix

BIO-35020 2000 rxns Ask for price

Human Genomic DNA

BIO-35025 500µl @ 200ng/µl Ask for price

DNA Extraction Control 670, (Red Cap)

BIO-35028 500 rxns Ask for price

DNA Extraction Control 670, (Red Cap)

BIO-35029 2000 rxns Ask for price

DNA Extraction Control 560 (Orange Cap)

BIO-35032 2000 rxns Ask for price

DNA Extraction Control 610 (Yellow Cap)

BIO-35033 500 rxns Ask for price

DNA Extraction Control 610 (Yellow Cap)

BIO-35034 2000 rxns Ask for price

NH4 Buffer, 10x

BIO-37025 3 x 1.2ml Ask for price

MgCl2 Solution, 50mM

BIO-37026 3 x 1.2ml Ask for price

X-GAL

BIO-37035 1g Ask for price

IPTG

BIO-37036 5g Ask for price

Proteinase K

BIO-37037 100mg Ask for price

Proteinase K

BIO-37039 1000mg Ask for price

DNA Loading Buffer Blue, 5x

BIO-37045 2 x 1ml Ask for price

SureClean Plus

BIO-37047 1 x 5ml Ask for price

SureClean Plus

BIO-37048 2 x 12.5ml Ask for price

Co-Precipitant, Pink

BIO-37075 1.5ml, 5mg/ml Ask for price

Proteinase K Solution

BIO-37084 5ml @ 20mg/ml Ask for price

Proteinase K Solution

BIO-37085 5 x 5ml @ 20mg/ml Ask for price

MangoTaq Buffer 5x, Colourless

BIO-37101 10ml Ask for price

MangoTaq Buffer 5x, Coloured

BIO-37102 10ml Ask for price

Hi-Fi Reaction Buffer, 5x

BIO-37110 2 x 1.5ml Ask for price

MyTaq reaction Buffer Colourless, 5x

BIO-37111 4 x 1ml Ask for price

MyTaq Reaction Buffer Red, 5x

BIO-37112 4 x 1ml Ask for price

RANGER Reaction Buffer, 5x

BIO-37114 3 x 1.25ml Ask for price

MyFi Reaction Buffer, 5x

BIO-37115 3 x 1.25ml Ask for price

BIO-37120 Ask for price

Random Hexamer Primer

BIO-38028 25µg Ask for price

Oligo (dT) 18

BIO-38029 27µg Ask for price

TRIsure

BIO-38032 100ml Ask for price

TRIsure

BIO-38033 200ml Ask for price

RNA Extraction Control 670

BIO-38040 100 Reactions Ask for price

RNA Extraction Control 670

BIO-38041 500 Reactions Ask for price

RNA Extraction Control 560

BIO-38044 100 Reactions Ask for price

RNA Extraction Control 560

BIO-38045 500 Reactions Ask for price

RNA Extraction Control 610

BIO-38048 100 Reactions Ask for price

RNA Extraction Control 610

BIO-38049 500 Reactions Ask for price

dNTP Set, 100mM

BIO-39025 4 x 25µmol, (4 x 250µl) Ask for price

dNTP Set, 100mM

BIO-39026 4 x 100µmol, (4 x 4 x 250µl) Ask for price

dNTP Mix, 100mM Final Conc.

BIO-39028 50µmol, (1 x 500µl) Ask for price

dNTP Mix, 100mM Final Conc.

BIO-39029 200µmol, (4 x 500µl) Ask for price

dUTP, 100mM

BIO-39035 25µmol, (1 x 250µl) Ask for price

dATP, 100mM

BIO-39036 25µmol, (1 x 250µl) Ask for price

dGTP, 100mM

BIO-39037 25µmol, (1 x 250µl) Ask for price

dCTP, 100mM

BIO-39038 25µmol, (1 x 250µl) Ask for price

dTTP, 100mM

BIO-39039 25µmol, (1 x 250µl) Ask for price

dUTP Mix, 50mM Final Conc.

BIO-39041 25µmol, (1 x 500µl) Ask for price

dNTP Mix, 40mM Final Conc.

BIO-39043 20µmol, (1 x 500µl) Ask for price

dNTP Mix, 10mM Final Conc.

BIO-39044 10µmol, (1ml vol.) Ask for price

EPIK Hydroxymethylated dCTP, 100mM

BIO-39046 25µmol, (1 x 250µl) Ask for price

dNTP Set, 100mM

BIO-39049 4 x 100µmol, (4 x 1ml) Ask for price

dNTP Mix, 10mM Final Conc.

BIO-39053 100µmol, (10 x 1ml) Ask for price

Agarose, Molecular Grade

BIO-41025 500g Ask for price

Agarose, Molecular Grade

BIO-41026 100g Ask for price

Agarose Tablets , DNase/RNase Free

BIO-41027 300g Ask for price

ISOLATE Fecal DNA Kit

BIO-52038 100 preps (Kit 2 x 50 preps) Ask for price

ISOLATE II Plasmid Mini Kit

BIO-52055 10 preps Ask for price

ISOLATE II Plasmid Mini Kit

BIO-52056 50 preps Ask for price

ISOLATE II Plasmid Mini Kit

BIO-52057 250 preps Ask for price

ISOLATE II PCR & Gel Kit

BIO-52058 10 preps Ask for price

ISOLATE II PCR & Gel Kit

BIO-52059 50 preps Ask for price

ISOLATE II PCR & Gel Kit

BIO-52060 250 preps Ask for price

ISOLATE II Blood DNA Kit

BIO-52062 10 Preps Ask for price

ISOLATE II Blood DNA Kit

BIO-52063 50 Preps Ask for price

ISOLATE II Genomic DNA Kit

BIO-52065 10 preps Ask for price

ISOLATE II Genomic DNA Kit

BIO-52066 50 preps Ask for price

ISOLATE II Genomic DNA Kit

BIO-52067 250 preps Ask for price

ISOLATE II Plant Kit

BIO-52068 10 preps Ask for price

ISOLATE II Plant Kit

BIO-52069 50 preps Ask for price

As thorough understanding of pharmacokinetics is critical in successful translation to the clinic, we expect that this review will provide a jumping off point for further investigations into this area.