The Dementias Platform UK (DPUK) Data Portal.

The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data.

All projects utilising the data are by default collaborations with the cohort research teams generating the data. The Data Portal uses UK Secure eResearch Platform infrastructure to provide three core utilities: data discovery, access, and analysis.

These are delivered using a 7 layered architecture comprising: data ingestion, data curation, platform interoperability, data discovery, access brokerage, data analysis and knowledge preservation.

Automated, streamlined, and standardised procedures reduce the administrative burden for all stakeholders, particularly for requests involving multiple independent datasets, where a single request may be forwarded to multiple data controllers.

Researchers are provided with their own secure ‘lab‘ using VMware which is accessed using two factor authentication. Over the last 2 years, 160 project proposals involving 579 individual cohort data access requests were received. These were received from 268 applicants spanning 72 institutions (56 academic, 13 commercial, 3 government) in 16 countries with 84 requests involving multiple cohorts.

alpha Actin antibody (cardiac)

10R-7942 100 ug
EUR 430
Description: Mouse monoclonal alpha Actin antibody (cardiac)

IL-8 (-5 to +5)

5-01377 4 x 5mg Ask for price

2',3',5'-triacetyl-5-Azacytidine

B2822-5
EUR 153

2',3',5'-triacetyl-5-Azacytidine

C4119-5 5 mg
EUR 118
Description: 2',3',5'-triacetyl-5-Azacytidine (TAC) is the lead prodrug form of 5-azacytidine which may be rapidly absorbed after oral administration [1]. 5-Azacytidine is an inhibitor of DNA methyltransferase [2].

Aftin-5

2575-5
EUR 457

CHD-5

2693-5
EUR 153

Necrostatin-5

1865-5
EUR 126

GNF-5

B1329-5
EUR 142

Histatin 5

5-01307 4 x 1mg Ask for price

5-Iodotubercidin

A3125-5 5 mg
EUR 168
Description: 5-Iodotubercidin (Itu) is a purine derivative and hence an inhibitor of adenosine kinase with an IC50 value of 26 nM [1]. Adenosine kinase is important in regulating the intracellular and extracellular concentrations of adenosine and hence diverse physiological actions of adenosine [2].

5-ROX

B8212-5 5 mg
EUR 195

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

A1036-5 5 mg
EUR 102
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5),(C30H50N8O7), a peptide with the sequence NH2-Ser-Phe-Leu-Leu-Arg-COOH, MW= 634.76. coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response.

2',5'-Dideoxyadenosine

2770-5
EUR 240

[Cit5]-TRAP-5

5-00062 4 x 5mg Ask for price

A-VI-5

5-00524 4 x 5mg Ask for price

ACTH(5-10)

5-00605 4 x 5mg Ask for price

Angiotensin (1-5)

5-00676 4 x 5mg Ask for price

Bradykinin (1-5)

5-00852 4 x 5mg Ask for price

TRAP-5 amide

5-02019 4 x 5mg Ask for price

Teicoplanin A2-5

C4938-5 5 mg
EUR 1157
Description: Teicoplanin A2-5, derived from Actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria.

5'-deoxy Thymidine

C4692-5 5 mg
EUR 180
Description: 5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines.

5-fluoro 203

C4114-5 5 mg
EUR 154
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450.

W-5 hydrochloride

B6277-5 5 mg
EUR 116

5-Nonyloxytryptamine oxalate

B6496-5 5 mg
EUR 154

5-Formylcytosine (5-fC) ELISA Kit

MET-5102-5 5 x 96 assays
EUR 2283

5-Carboxylcytosine (5-caC) ELISA Kit

MET-5103-5 5 x 96 assays
EUR 2283

AICA riboside, 5'-phosphate

9416-5
EUR 153

Individual Reaction Mix 5

G065-5 200 reactions
EUR 167

Necrosis Inhibitor, Necrox-5

2229-5
EUR 615

5-Nitroso-8-quinolinol

B2825-5
EUR 109

Dok- 5 (263 - 275)

5-01048 4 x 5mg Ask for price

Secretin (5 - 27), porcine

5-01917 4 x 1mg Ask for price

SH2 Domain Ligand (5)

5-01929 4 x 5mg Ask for price

Boc-5-Ava-OH

5-04607 25g Ask for price

Boc-5-Ava-OH

5-04608 100g Ask for price

Fmoc-5-Ava-OH

5-04609 5g Ask for price

Fmoc-5-Ava-OH

5-04610 25g Ask for price

FAM azide, 5- isomer

A8117-5 5 mg
EUR 166
Description: FAM azide for Click chemistry labeling. FAM remains one of the most popular fluorescent lablels for various application. Most instruments capable of fluorescence detection, ranging from plate readers to fluorescence microscopes, are able to work in FAM channel.

ROX azide, 5- isomer

A8126-5 5 mg
EUR 583
Description: ROX (rhodamine-X) azide, solid material, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. ROX is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield.Pure 5-isomer.

TAMRA azide, 5- isomer

A8129-5 5 mg
EUR 583
Description: TAMRA (TMR, tetramethylrhodamine) azide, solid compound, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. Pure 5-isomer.TAMRA is often used as FRET acceptor for FAM fluorophore.

5'-(N-Cyclopropyl)carboxamidoadenosine

C4645-5 5 mg
EUR 128

5-trans U-46619

C4261-5 5 mg
EUR 538
Description: 5-trans U-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of U-46619 [1]. U-46619 is a selective thromboxane A2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2].

2',5'-dideoxy Adenosine

C3993-5 5 mg
EUR 189
Description: 2',5'-dideoxy Adenosine, a nucleoside analog, is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase [1]. Adenylyl cyclase is an enzyme with key regulatory roles in almost all cells.

2-Methyl-5-hydroxytryptamine hydrochloride

2768-5
EUR 185

3,3',5'-Triiodo-L-thyronine

B2017-5
EUR 229

pLenti-CLDN1 shRNA-5 Plasmid

PVTBAV04867-5 2 ug
EUR 356

[Pyr5]-Substance P (5-11)

5-00288 4 x 5mg Ask for price

[Trp3, Arg5]-Ghrelin (1-5)

5-00313 4 x 5mg Ask for price

beta-Casomorphin (1-5) (bovine)

5-00475 4 x 5mg Ask for price

Angiotensin I/II (5-8)

5-00684 4 x 5mg Ask for price

Cholecystokinin Octapeptide (1-5) (desulfated)

5-00970 4 x 5mg Ask for price

HIV-gp41-Antigenic Peptide 5

5-01331 4 x 1mg Ask for price

Fmoc-Trp(5-OH)-OH

5-06939 5g Ask for price

Fmoc-Trp(5-OH)-OH

5-06940 25g Ask for price

Magnetic Beads (DNA) 5 mL

P920-5 - Ask for price

Angiotensin 1/2 (1-5)

A1047-5 5 mg
EUR 119
Description: Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.Angiotensin I is formed by the action ofreninonangiotensinogen, an ?-2-globulin with 12 amino acids.

Angiotensin 1/2 (5-7)

A1049-5 5 mg
EUR 119
Description: Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

3,3',5'-Triiodo-L-thyronine

C5014-5 5 mg
EUR 134
Description: 3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TR? and TR? antagonist [1].

2'-O-Methylpseudouridine-5'-Triphosphate

B7993-.5 5x100 µl (100 mM)
EUR 14023

2'-Fluoro-thymidine-5'-Triphosphate

B8035-.5 5x100 µl (100 mM)
EUR 2059

Helioxanthin derivative 5-4-2

B4700-5 5 mg
EUR 683
Description: Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 ?M, 0.29 ?M and 0.16 ?M, respectively [1].

5?-dihydro-11-keto Testosterone

C4317-5 5 mg
EUR 586
Description: 5?-dihydro-11-keto Testosterone (11KDHT) is a full androgen receptor agonist comparable to dihydrotestosterone (DHT) [1][2][3].

Nickel NTA Magnetic Agarose Bead (5%)

MagNTANi5-5 5ml suspension
EUR 174

beta-Casomorphin (1-5) amide (bovine)

5-00476 4 x 5mg Ask for price

cAMP Dependent PK Inhibitor (5-24)

5-00922 4 x 1mg Ask for price

Kinase Domain of Insulin Receptor (5)

5-01429 4 x 1mg Ask for price

Fmoc-D-Trp(5-Br)-OH

5-04217 1g Ask for price

Fmoc-D-Trp(5-Br)-OH

5-04218 5g Ask for price

Fmoc-D-Trp(5-Cl)-OH

5-04223 1g Ask for price

Fmoc-D-Trp(5-Cl)-OH

5-04224 5g Ask for price

Fmoc-D-Trp(5-F)-OH

5-04227 1g Ask for price

Fmoc-D-Trp(5-F)-OH

5-04228 5g Ask for price

Ac-DL-Trp(5-Br)-OH·DCHA

5-04229 1g Ask for price

Ac-DL-Trp(5-Br)-OH·DCHA

5-04230 5g Ask for price

Ac-DL-Trp(5-Cl)-OH·DCHA

5-04231 1g Ask for price

Ac-DL-Trp(5-Cl)-OH·DCHA

5-04232 5g Ask for price

Fmoc-2-amino-5-Methoxybenzoic acid

5-04549 1g Ask for price

Fmoc-2-amino-5-Methoxybenzoic acid

5-04550 5g Ask for price

Fmoc-3-Ala(5-Thiazoyl)-OH

5-05361 1g Ask for price

Fmoc-3-Ala(5-Thiazoyl)-OH

5-05362 5g Ask for price

7078D 5 PIPET 5ML STERILE STERILE

7078D-5 25/pk
EUR 217
Description: Disposable Pipets; Disposable Pipets, Serological, Misc

Beta-Sheet Breaker Peptide iA?5

A1005-5 5 mg
EUR 102
Description: Beta-Sheet Breaker Peptide iA?5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models.

2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate

B7959-.5 5x100 µl (100 mM)
EUR 2059

2'-Fluoro-2'-deoxycytidine-5'-Triphosphate

B7961-.5 5x100 µl (100 mM)
EUR 2059

2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate

B7962-.5 5x100 µl (100 mM)
EUR 2059

2'-Fluoro-2'-deoxyuridine-5'-Triphosphate

B7963-.5 5x100 µl (100 mM)
EUR 2059

3-bromo-5-phenyl Salicylic Acid

C4516-5 5 mg
EUR 370
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor.

5-bromo-3-phenyl Salicylic Acid

C4610-5 5 mg
EUR 319

5-(N,N-dimethyl)-Amiloride (hydrochloride)

C3505-5 5 mg
EUR 180
Description: 5-(N, N-dimethyl)-Amiloride (hydrochloride), a derivative of amiloride, is an inhibitor of NHE1, NHE2, and NHE3. The Na+/H+ exchanger (NHE) is a protein that has been involved in intracellular pH homeostasis of many mammalian cell types.

CytoSelect Clonogenic Tumor Cell Isolation Kit (5 x 5 preps)

CBA-155-5 25 preps
EUR 3245
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis.

5-Hydroxytryptamine (5-HT) ELISA Kit

DLR-5-HT-Ge-48T 48T
EUR 469
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids.

5-Hydroxytryptamine (5-HT) ELISA Kit

DLR-5-HT-Ge-96T 96T
EUR 608
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids.

S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

B2826-5
EUR 120

[D-Ala2]- beta-Casomorphin (1-5), bovine

5-00075 4 x 5mg Ask for price

[D-Pro2]-beta-Casomorphin (1-5) , bovine

5-00133 4 x 5mg Ask for price

beta-Endorphin (1-5) + (16-31), human

5-00488 4 x 1mg Ask for price

Biotin-Kinase Domain of Insulin Receptor (5)

5-00799 4 x 1mg Ask for price

cAMP Dependent PK Inhibitor (5-22), amide

5-00921 4 x 1mg Ask for price

Substance P (5-11)/Hepta-Substance P

5-01979 4 x 5mg Ask for price

DiagNano Silica-Coated Gold Nanoparticles, 5 nm

CG-5 10mL
EUR 719

5-min. Genomic DNA Prep for PCR

P930-5 - Ask for price

DiagNano Fluorophore Labeled Gold Nanoparticles, 5 nm

GFL-5 1 mL
EUR 1053

2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide

C4686-5 5 mg
EUR 232

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

DLR-5-HIAA-Ge-48T 48T
EUR 575
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids.

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

DLR-5-HIAA-Ge-96T 96T
EUR 753
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids.

General 5-Hydroxytryptamine (5-HT) ELISA Kit

RD-5-HT-Ge-48Tests 48 Tests
EUR 467

General 5-Hydroxytryptamine (5-HT) ELISA Kit

RD-5-HT-Ge-96Tests 96 Tests
EUR 646

General 5-Hydroxytryptamine (5-HT) ELISA Kit

RDR-5-HT-Ge-48Tests 48 Tests
EUR 488

General 5-Hydroxytryptamine (5-HT) ELISA Kit

RDR-5-HT-Ge-96Tests 96 Tests
EUR 676

Checkit Pro C02 - 5 pack

CP-C02-5 5pack
EUR 207
Description: Pipette Checkit Pro model for 2uL pipettes. Pack of 5.

Checkit Pro C05 - 5 pack

CP-C05-5 5pack
EUR 198
Description: Pipette Checkit Pro model for 5uL pipettes. Pack of 5.

Checkit Pro C10 - 5 pack

CP-C10-5 5pack
EUR 198
Description: Pipette Checkit Pro model for 10uL pipettes. Pack of 5.

Checkit Pro C100 - 5 pack

CP-C100-5 5pack
EUR 179
Description: Pipette Checkit Pro model for 100uL pipettes. Pack of 5.

Checkit Pro C20 - 5 pack

CP-C20-5 5pack
EUR 188
Description: Pipette Checkit Pro model for 20uL pipettes. Pack of 5.

Checkit Pro C200 - 5 pack

CP-C200-5 5pack
EUR 179
Description: Pipette Checkit Pro model for 200uL pipettes. Pack of 5.

Checkit Pro C50 - 5 pack

CP-C50-5 5pack
EUR 179
Description: Pipette Checkit Pro model for 50uL pipettes. Pack of 5.

[D-Ala2]- beta-Casomorphin (1-5) amide (bovine)

5-00074 4 x 5mg Ask for price

[D-Ala2, Met5]- ß-Casomorphin (1-5), bovine

5-00092 4 x 5mg Ask for price

[D-Pro2]-beta-Casomorphin (1-5) , bovine, amide

5-00134 4 x 5mg Ask for price

DiagNano Gold Nanoparticle Passive Conjugation Kit, 5 nm

GPK-5 1 kit
EUR 715

DiagNano Silica-Coated PEGylated Gold Nanoparticles, 5 nm

PG-5 10mL
EUR 719

General 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

RDR-5-HIAA-Ge-48Tests 48 Tests
EUR 613

General 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

RDR-5-HIAA-Ge-96Tests 96 Tests
EUR 854

[D-Ala2, DPro4, Tyr5] -beta-Casomorphin (1-5), amide

5-00089 4 x 5mg Ask for price

[D-Ala2, Hyp4, Tyr5]- beta-Casomorphin (1-5) amide

5-00090 4 x 5mg Ask for price

[D-Ala2, Met5]- beta-Casomorphin (1-5) , bovine , amide

5-00093 4 x 5mg Ask for price

survivin (baculoviral IAP repeat-containing protein 5) (21-28)

A1092-5 5 mg
EUR 224
Description: Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibition of apoptosis and mitosis regulation1.

Single channel mini-pipette (130 mm) 5 ul, autoclavable

SCMP-5 1
EUR 92

Sodium chloride 5 M, 1000 ml

12-9191-5 1000 ml
EUR 96

OxiSelect Nitrotyrosine ELISA Kit (5 plates)

STA-305-5 5 x 96 assays
EUR 3240
Description: Nitric oxide influences a variety of biological processes including cell proliferation, apoptosis, neurotoxicity and extracellular matrix remodeling. Nitric oxide reacts with superoxide to form peroxynitrite, which in turn nitrates tyrosine residues in proteins. Nitrotyrosine therefore serves as a marker for peroxynitrite action in a variety of disease states and in conditions of cellular damage and oxidative stress. Our OxiSelect Nitrotyrosine ELISA Kit provides a sensitive method to measure the formation of 3-nitrotyrosine in proteins.

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit

DLR-CA19-5-Hu-48T 48T
EUR 554
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-5 (CA19-5) in samples from serum, plasma or other biological fluids.

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit

DLR-CA19-5-Hu-96T 96T
EUR 725
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-5 (CA19-5) in samples from serum, plasma or other biological fluids.

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit

RD-CA19-5-Hu-48Tests 48 Tests
EUR 563

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit

RD-CA19-5-Hu-96Tests 96 Tests
EUR 783

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit

RDR-CA19-5-Hu-48Tests 48 Tests
EUR 589

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit

RDR-CA19-5-Hu-96Tests 96 Tests
EUR 820

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (5 biotin/BSA)

7098-5
EUR 120

[D-Ala2, 4, Tyr5] -beta-Casomorphin (1-5), amide, bovine

5-00085 4 x 5mg Ask for price

[D-Glu5, D-Trp7, 9, 10]-Substance P (5-11)

5-00114 4 x 5mg Ask for price

[Des-Ala1, des-Gly2, His4, 5, D-Trp8]-Somatostatin-14

5-00162 4 x 5mg Ask for price

Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat)

5-01665 4 x 5mg Ask for price

Protein G Affinity Cartridges 5ml,1 or 5 cartridges with 5 ml of resin each one

AF4PG-Ctg5-5 5 x 5ml
EUR 726

Nickel NTA Agarose Cartridges 5ml,1 or 5 cartridges with 5 ml of resin each one

6BCL-NTANiCtg5-5 5 x 5ml
EUR 411

Sodium hydroxide powder 5 M, 1000 ml

12-9183-5 1000 ml
EUR 122

OxiSelect Protein Carbonyl ELISA Kit (5 plates)

STA-310-5 5 x 96 assays
EUR 3240
Description: The most common products of protein oxidation in biological samples are the carbonyl derivatives of proline, lysine, arginine and threonine residues. Such derivatives are chemically stable and serve as markers for oxidative stress in most types of reactive oxygen species. Our OxiSelect Protein Carbonyl ELISA Kit provides a rapid, efficient method for the detection of protein carbonyl residues. The ELISA format is perfect for higher throughput and high sensitivity; we have eliminated concentration and precipitation steps allowing greater sample retention.

Human Angiotensin II (5-8), pure (bioactive)

AT69-P-5 5 mg
EUR 286

Nuclear Membrane Marker; Clone AE-5 (Concentrate)

RA0402-C.5 0.5 ml
EUR 300

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1030-5
EUR 664

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1031-5
EUR 664

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)

M1032-5
EUR 664

Projects are varied including multi-modal, machine learning, and Mendelian randomisation analyses. Data access is usually free at point of use although a small number of cohorts require a data access fee.